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Flavones enhance the neurotrophic effects of BDNF by reinforcing TrkB receptor signaling (Wang et al., 2021

Both were removed from FDA 503A Category 2 on April 22, 2026, but neither is on Category 1 either

10.1089/ars.2022.0206 2 AlaM.AlaM

it competitively binds to cellular receptors, blocking the body's natural active B6 and potentially inducing a functional deficiency that leads to peripheral neuropathy (nerve tingling and pain)

The Ontario Drug Benefit (ODB) database was used to identify patients who were prescribed vitamin B12 injections, and the Ontario Health Insurance Plan database was used to identify all physician claims for intramuscular injections as well as laboratory tests assessing vitamin B12 levels